Ontology highlight
ABSTRACT:
SUBMITTER: Binder M
PROVIDER: S-EPMC5709752 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Binder M M Rajkumar S V SV Ketterling R P RP Greipp P T PT Dispenzieri A A Lacy M Q MQ Gertz M A MA Buadi F K FK Hayman S R SR Hwa Y L YL Zeldenrust S R SR Lust J A JA Russell S J SJ Leung N N Kapoor P P Go R S RS Gonsalves W I WI Kyle R A RA Kumar S K SK
Blood cancer journal 20170901 9
Fluorescence in situ hybridization evaluation is essential for initial risk stratification in multiple myeloma. While the presence of specific cytogenetic high-risk abnormalities (HRA) is known to confer a poor prognosis, less is known about the cumulative effect of multiple HRA. We studied 1181 patients with newly diagnosed multiple myeloma who received novel agents as first-line therapy. High-risk abnormalities were defined as t(4;14), t(14;16), t(14;20) and del(17p). There were 884 patients ( ...[more]