Safety of Converting From Tetrabenazine to Deutetrabenazine for the Treatment of Chorea.

ABSTRACT:

Importance

Tetrabenazine is efficacious for chorea control; however, tolerability concerns exist. Deutetrabenazine, a novel molecule that reduces chorea, was well tolerated in a double-blind, placebo-controlled study.

Objectives

To evaluate the safety and explore the efficacy of conversion from tetrabenazine to deutetrabenazine in patients with chorea associated with Huntington disease (HD).

Design, setting, and participants

In this ongoing, open-label, single-arm study that started on December 21, 2013, 37 patients at 13 Huntington Study Group sites in the United States and Australia who were taking stable doses of tetrabenazine that provided a therapeutic benefit were switched overnight to deutetrabenazine therapy. After week 1, the deutetrabenazine dose was titrate

SUBMITTER: Frank S 

PROVIDER: S-EPMC5710322 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature