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Detection of adamantane-sensitive influenza A(H3N2) viruses in Australia, 2017: a cause for hope?

ABSTRACT: For over a decade virtually all A(H3N2) influenza viruses have been resistant to the adamantane class of antivirals. However, during the 2017 influenza season in Australia, 15/461 (3.3%) adamantane-sensitive A(H3N2) viruses encoding serine at residue 31 of the M2 protein were detected, more than the total number identified globally during the last 6 years. A return to wide circulation of adamantane-sensitive A(H3N2) viruses would revive the option of using these drugs for treatment and prophylaxis.

SUBMITTER: Hurt A 

PROVIDER: S-EPMC5710658 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Detection of adamantane-sensitive influenza A(H3N2) viruses in Australia, 2017: a cause for hope?

Hurt Aeron A   Komadina Naomi N   Deng Yi-Mo YM   Kaye Matthew M   Sullivan Sheena S   Subbarao Kanta K   Barr Ian I  

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20171101 47

For over a decade virtually all A(H3N2) influenza viruses have been resistant to the adamantane class of antivirals. However, during the 2017 influenza season in Australia, 15/461 (3.3%) adamantane-sensitive A(H3N2) viruses encoding serine at residue 31 of the M2 protein were detected, more than the total number identified globally during the last 6 years. A return to wide circulation of adamantane-sensitive A(H3N2) viruses would revive the option of using these drugs for treatment and prophylax  ...[more]

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