Ontology highlight
ABSTRACT:
SUBMITTER: Pasek RC
PROVIDER: S-EPMC5710701 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Pasek Raymond C RC Dunn Jennifer C JC Elsakr Joseph M JM Aramandla Mounika M Matta Anveetha R AR Gannon Maureen M
Islets 20171107 6
During pregnancy, maternal β cells undergo compensatory changes including hypertrophy, hyperplasia, and increased glucose-stimulated insulin secretion (GSIS). Failure of these adaptations to occur can result in gestational diabetes mellitus. The secreted protein, Connective tissue growth factor (Ctgf), is critical for normal β cell development and promotes regeneration after partial β cell ablation. During embryogenesis, Ctgf is expressed in pancreatic ducts, vasculature, and β cells. In the adu ...[more]