Ontology highlight
ABSTRACT:
SUBMITTER: Debattisti V
PROVIDER: S-EPMC5710826 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Debattisti Valentina V Gerencser Akos A AA Saotome Masao M Das Sudipto S Hajnóczky György G
Cell reports 20171101 6
Mitochondrial distribution and motility are recognized as central to many cellular functions, but their regulation by signaling mechanisms remains to be elucidated. Here, we report that reactive oxygen species (ROS), either derived from an extracellular source or intracellularly generated, control mitochondrial distribution and function by dose-dependently, specifically, and reversibly decreasing mitochondrial motility in both rat hippocampal primary cultured neurons and cell lines. ROS decrease ...[more]