The role of Allee effect in modelling post resection recurrence of glioblastoma.
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ABSTRACT:
SUBMITTER: Neufeld Z
PROVIDER: S-EPMC5711030 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
The role of Allee effect in modelling post resection recurrence of glioblastoma.
Neufeld Zoltan Z von Witt William W Lakatos Dora D Wang Jiaming J Hegedus Balazs B Czirok Andras A
PLoS computational biology 20171117 11
Resection of the bulk of a tumour often cannot eliminate all cancer cells, due to their infiltration into the surrounding healthy tissue. This may lead to recurrence of the tumour at a later time. We use a reaction-diffusion equation based model of tumour growth to investigate how the invasion front is delayed by resection, and how this depends on the density and behaviour of the remaining cancer cells. We show that the delay time is highly sensitive to qualitative details of the proliferation d ...[more]
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