IL-1? Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase.
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ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC5711380 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
IL-1β Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase.
Yu Jie J Berga Sarah L SL Zou Wei W Yook D Grace DG Pan Joshua C JC Andrade Aurora Arroyo AA Zhao Lijuan L Sidell Neil N Bagchi Indrani C IC Bagchi Milan K MK Taylor Robert N RN
Endocrinology 20171201 12
Inflammation can interfere with endometrial receptivity. We examined how interleukin 1β (IL-1β) affects expression of the uterine gap junction protein connexin 43 (Cx43), which is known to be critical for embryonic implantation. We used an in vitro model of human endometrial stromal cells (ESCs), Western blotting, and a combination of validated, selective kinase inhibitors to evaluate five canonical IL-1β signaling pathways. Cx43 and two other markers of ESC differentiation (prolactin and VEGF) ...[more]
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