Antimicrobial capacity of the freshwater planarians against S. aureus is under the control of Timeless.
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ABSTRACT:
SUBMITTER: Tsoumtsa LL
PROVIDER: S-EPMC5711420 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Antimicrobial capacity of the freshwater planarians against S. aureus is under the control of Timeless.
Tsoumtsa Landry Laure LL Torre Cedric C Trouplin Virginie V Coiffard Benjamin B Gimenez Gregory G Mege Jean-Louis JL Ghigo Eric E
Virulence 20170104 7
Planarians, which are non-parasitic flatworms, are highly resistant to bacterial infections. To better understand the mechanisms underlying this resistance, we investigated the role of the circadian machinery in the anti-bacterial response of the freshwater planarian Schmidtea mediterranea. We identified Smed-Tim from S. mediterranea as a homolog of the mammalian clock gene Tim. We showed via RNA interference that Smed-Tim is required for the anti-microbial activities of Schmidtea mediterranea a ...[more]
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