Ontology highlight
ABSTRACT:
SUBMITTER: Chang E
PROVIDER: S-EPMC5711586 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Chang Edwin E Pohling Christoph C Beygui Nooshin N Patel Chirag B CB Rosenberg Jarrett J Ha Dong Ho DH Gambhir Sanjiv S SS
Journal of neuro-oncology 20170705 2
Glioblastoma (GBM) is the most aggressive and lethal form of brain cancer. Standard therapies are non-specific and often of limited effectiveness; thus, efforts are underway to uncover novel, unorthodox therapies against GBM. In previous studies, we investigated Withaferin A, a steroidal lactone from Ayurvedic medicine that inhibits proliferation in cancers including GBM. Another novel approach, tumor treating fields (TTFields), is thought to disrupt mitotic spindle formation and stymie prolifer ...[more]