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Alternative activation generates IL-10 producing type 2 innate lymphoid cells.


ABSTRACT: Type 2 innate lymphoid cells (ILC2) share cytokine and transcription factor expression with CD4+ Th2 cells, but functional diversity of the ILC2 lineage has yet to be fully explored. Here, we show induction of a molecularly distinct subset of activated lung ILC2, termed ILC210. These cells produce IL-10 and downregulate some pro-inflammatory genes. Signals that generate ILC210 are distinct from those that induce IL-13 production, and gene expression data indicate that an alternative activation pathway leads to the generation of ILC210. In vivo, IL-2 enhances ILC210 generation and is associated with decreased eosinophil recruitment to the lung. Unlike most activated ILC2, the ILC210 population contracts after cessation of stimulation in vivo, with maintenance of a subset that can be recalled by restimulation, analogous to T-cell effector cell and memory cell generation. These data demonstrate the generation of a previously unappreciated IL-10 producing ILC2 effector cell population.

SUBMITTER: Seehus CR 

PROVIDER: S-EPMC5711851 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Alternative activation generates IL-10 producing type 2 innate lymphoid cells.

Seehus Corey R CR   Kadavallore Asha A   Torre Brian de la B   Yeckes Alyson R AR   Wang Yizhou Y   Tang Jie J   Kaye Jonathan J  

Nature communications 20171201 1


Type 2 innate lymphoid cells (ILC2) share cytokine and transcription factor expression with CD4<sup>+</sup> T<sub>h</sub>2 cells, but functional diversity of the ILC2 lineage has yet to be fully explored. Here, we show induction of a molecularly distinct subset of activated lung ILC2, termed ILC2<sub>10</sub>. These cells produce IL-10 and downregulate some pro-inflammatory genes. Signals that generate ILC2<sub>10</sub> are distinct from those that induce IL-13 production, and gene expression da  ...[more]

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