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Screening and identification of lncRNAs as potential biomarkers for pulmonary tuberculosis.


ABSTRACT: Pulmonary tuberculosis (TB) is among the diseases with the highest morbidity and mortality worldwide. Effective diagnostic methods for TB are lacking. In this study, we investigated long non-coding RNAs (lncRNAs) in plasma using microarray and the potential diagnostic value of lncRNAs for TB. We found a total of 163 up-regulated lncRNAs and 348 down-regulated lncRNAs. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and coding-noncoding co-expression (CNC) analyses showed that functions of differentially expressed lncRNAs were mainly enriched in the regulation of alpha-beta T cell activation and the T cell receptor signalling pathway. Four differentially expressed lncRNAs, NR_038221 (fold change?=?3.79, P?

SUBMITTER: Chen ZL 

PROVIDER: S-EPMC5711916 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Screening and identification of lncRNAs as potential biomarkers for pulmonary tuberculosis.

Chen Zhong-Liang ZL   Wei Li-Liang LL   Shi Li-Ying LY   Li Meng M   Jiang Ting-Ting TT   Chen Jing J   Liu Chang-Ming CM   Yang Su S   Tu Hui-Hui HH   Hu Yu-Ting YT   Gan Lin L   Mao Lian-Gen LG   Wang Chong C   Li Ji-Cheng JC  

Scientific reports 20171201 1


Pulmonary tuberculosis (TB) is among the diseases with the highest morbidity and mortality worldwide. Effective diagnostic methods for TB are lacking. In this study, we investigated long non-coding RNAs (lncRNAs) in plasma using microarray and the potential diagnostic value of lncRNAs for TB. We found a total of 163 up-regulated lncRNAs and 348 down-regulated lncRNAs. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and coding-noncoding co-expression (CNC) analyses showed that  ...[more]

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