Lack of Effectiveness of Postchemotherapy Lymphadenectomy in Bladder Cancer Patients with Clinical Evidence of Metastatic Pelvic or Retroperitoneal Lymph Nodes Only: A Propensity Score-based Analysis.

ABSTRACT:

Background

Limited data is available on the role, and extent of, postchemotherapy lymphadenectomy (PC-LND) in patients with clinical evidence of pelvic (cN1-3) or retroperitoneal (RP) lymph node spread from urothelial bladder carcinoma.

Objective

To compare the outcomes of operated versus nonoperated patients after first-line chemotherapy.

Design, setting, and participants

Data from 34 centers was collected, totaling 522 patients, treated between January 2000 and June 2015. Criteria for patient selection were the following: bladder primary tumor, lymph node metastases (pelvic±RP) only, first-line platinum-based chemotherapy given.

Intervention

LND (with cystectomy) versus observation after first-line chemotherapy for metastatic urothelial bladder carcinoma.

SUBMITTER: Necchi A 

PROVIDER: S-EPMC5712487 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature