Ontology highlight
ABSTRACT:
SUBMITTER: Guberina H
PROVIDER: S-EPMC5713307 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Guberina Hana H Tomoya Michita Rafael R Dolff Sebastian S Bienholz Anja A Trilling Mirko M Heinemann Falko M FM Horn Peter A PA Kribben Andreas A Witzke Oliver O Rebmann Vera V
International journal of molecular sciences 20171105 11
The expression modulation of the immunosuppressive non-classical Human leukocyte antigen-G (HLA-G) molecule and its soluble isoforms is an immune evasion strategy being deployed by cytomegalovirus (CMV). The +3142 C>G single nucleotide polymorphism (SNP) located within the 3' untranslated region (3'UTR) is of crucial importance for the regulation of HLA-G expression. Therefore, we analyzed the influence of the +3142 C>G HLA-G SNP on the occurrence of CMV infection in a cohort of 178 living-donor ...[more]