Ontology highlight
ABSTRACT:
SUBMITTER: Pellegrini C
PROVIDER: S-EPMC5713451 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Pellegrini Cristina C Maturo Maria Giovanna MG Di Nardo Lucia L Ciciarelli Valeria V Gutiérrez García-Rodrigo Carlota C Fargnoli Maria Concetta MC
International journal of molecular sciences 20171122 11
Basal cell carcinoma (BCC) is the most common human cancer and represents a growing public health care problem. Several tumor suppressor genes and proto-oncogenes have been implicated in BCC pathogenesis, including the key components of the Hedgehog pathway, <i>PTCH</i>1 and <i>SMO</i>, the <i>TP</i>53 tumor suppressor, and members of the <i>RAS</i> proto-oncogene family. Aberrant activation of the Hedgehog pathway represents the molecular driver in basal cell carcinoma pathogenesis, with the ma ...[more]