Ontology highlight
ABSTRACT:
SUBMITTER: Pesce L
PROVIDER: S-EPMC5713697 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Pesce Luca L Calandrini Vania V Marjault Henri-Baptiste HB Lipper Colin H CH Rossetti Gulia G Mittler Ron R Jennings Patricia A PA Bauer Andreas A Nechushtai Rachel R Carloni Paolo P
The journal of physical chemistry. B 20171116 47
The NEET proteins are a novel family of iron-sulfur proteins characterized by an unusual three cysteine and one histidine coordinated [2Fe-2S] cluster. Aberrant cluster release, facilitated by the breakage of the Fe-N bond, is implicated in a variety of human diseases, including cancer. Here, the molecular dynamics in the multi-microsecond timescale, along with quantum chemical calculations, on two representative members of the family (the human NAF-1 and mitoNEET proteins), show that the loss o ...[more]