Ontology highlight
ABSTRACT:
SUBMITTER: Mellenius H
PROVIDER: S-EPMC5714138 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Mellenius Harriet H Ehrenberg Måns M
Nucleic acids research 20171101 20
We suggest a novel two-step proofreading mechanism with two sequential rounds of proofreading selection in mRNA transcription. It is based on the previous experimental observations that the proofreading RNA polymerase cleaves off transcript fragments of at least 2 nt and that transcript elongation after a nucleotide misincorporation is anomalously slow. Taking these results into account, we extend the description of the accuracy of template guided nucleotide selection beyond previous models of R ...[more]