Ontology highlight
ABSTRACT:
SUBMITTER: Cheignon C
PROVIDER: S-EPMC5714184 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Cheignon Clémence C Faller Peter P Testemale Denis D Hureau Christelle C Collin Fabrice F
Metallomics : integrated biometal science 20161001 10
In the context of Alzheimer's disease (AD), the production of HO˙ by copper-amyloid beta (Aβ) in the presence of ascorbate is known to be deleterious for the Aβ peptide itself and also for the surrounding molecules, thus establishing a direct link between AD and oxidative stress. The metal-catalyzed oxidation (MCO) of Aβ primarily targets the residues involved in copper coordination during HO˙ production. In the present work, we demonstrate that the oxidative damage undergone by Aβ during MCO le ...[more]