Ontology highlight
ABSTRACT:
SUBMITTER: Conte-Daban A
PROVIDER: S-EPMC5714188 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Conte-Daban Amandine A Borghesani Valentina V Sayen Stéphanie S Guillon Emmanuel E Journaux Yves Y Gontard Geoffrey G Lisnard Laurent L Hureau Christelle C
Analytical chemistry 20170125 3
Being able to easily determine the Cu(II) affinity for biomolecules of moderate affinity is important. Such biomolecules include amyloidogenic peptides, such as the well-known amyloid-β peptide involved in Alzheimer's disease. Here, we report the synthesis of a new water-soluble ratiometric Cu(II) dye with a moderate affinity (10<sup>9</sup> M<sup>-1</sup> at pH 7.1) and the characterizations of the Cu(II) corresponding complex by X-ray crystallography, EPR, and XAS spectroscopic methods. UV-vis ...[more]