Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate.
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ABSTRACT:
SUBMITTER: Jasinska AJ
PROVIDER: S-EPMC5714271 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate.
Jasinska Anna J AJ Zelaya Ivette I Service Susan K SK Peterson Christine B CB Cantor Rita M RM Choi Oi-Wa OW DeYoung Joseph J Eskin Eleazar E Fairbanks Lynn A LA Fears Scott S Furterer Allison E AE Huang Yu S YS Ramensky Vasily V Schmitt Christopher A CA Svardal Hannes H Jorgensen Matthew J MJ Kaplan Jay R JR Villar Diego D Aken Bronwen L BL Flicek Paul P Nag Rishi R Wong Emily S ES Blangero John J Dyer Thomas D TD Bogomolov Marina M Benjamini Yoav Y Weinstock George M GM Dewar Ken K Sabatti Chiara C Wilson Richard K RK Jentsch J David JD Warren Wesley W Coppola Giovanni G Woods Roger P RP Freimer Nelson B NB
Nature genetics 20171030 12
By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune f ...[more]
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