Ontology highlight
ABSTRACT:
SUBMITTER: Sherwood AM
PROVIDER: S-EPMC5714653 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Sherwood Anna M AM Emerson Ryan O RO Scherer Dominique D Habermann Nina N Buck Katharina K Staffa Jürgen J Desmarais Cindy C Halama Niels N Jaeger Dirk D Schirmacher Peter P Herpel Esther E Kloor Matthias M Ulrich Alexis A Schneider Martin M Ulrich Cornelia M CM Robins Harlan H
Cancer immunology, immunotherapy : CII 20130616 9
Tumors from colorectal cancer (CRC) are generally immunogenic and commonly infiltrated with T lymphocytes. However, the details of the adaptive immune reaction to these tumors are poorly understood. We have accrued both colon tumor samples and adjacent healthy mucosal samples from 15 CRC patients to study lymphocytes infiltrating these tissues. We apply a method for detailed sequencing of T-cell receptor (TCR) sequences from tumor-infiltrating lymphocytes (TILs) in CRC tumors at high throughput ...[more]