Ontology highlight
ABSTRACT:
SUBMITTER: Yan CS
PROVIDER: S-EPMC5715166 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Yan Ching-Cher Sanders CS Chepyala Surendhar Reddy SR Yen Chao-Ming CM Hsu Chao-Ping CP
Scientific reports 20171204 1
Gene expression involves bursts of production of both mRNA and protein, and the fluctuations in their number are increased due to such bursts. The Langevin equation is an efficient and versatile means to simulate such number fluctuation. However, how to include these mRNA and protein bursts in the Langevin equation is not intuitively clear. In this work, we estimated the variance in burst production from a general gene expression model and introduced such variation in the Langevin equation. Our ...[more]