New insights into influenza A specificity: an evolution of paradigms.
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ABSTRACT:
SUBMITTER: Ji Y
PROVIDER: S-EPMC5715462 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
New insights into influenza A specificity: an evolution of paradigms.
Ji Ye Y White Yohanna Jb YJ Hadden Jodi A JA Grant Oliver C OC Woods Robert J RJ
Current opinion in structural biology 20170601
Understanding the molecular origin of influenza receptor specificity is complicated by the paucity of quantitative affinity measurements, and the qualitative and variable nature of glycan array data. Further obstacles arise from the varied impact of viral glycosylation and the relatively narrow spectrum of biologically relevant receptors present on glycan arrays. A survey of receptor conformational properties is presented, leading to the conclusion that conformational entropy plays a key role in ...[more]
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