Ontology highlight
ABSTRACT:
SUBMITTER: Aron AT
PROVIDER: S-EPMC5715752 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Aron Allegra T AT Heffern Marie C MC Lonergan Zachery R ZR Vander Wal Mark N MN Blank Brian R BR Spangler Benjamin B Zhang Yaofang Y Park Hyo Min HM Stahl Andreas A Renslo Adam R AR Skaar Eric P EP Chang Christopher J CJ
Proceedings of the National Academy of Sciences of the United States of America 20171114 48
Iron is an essential metal for all organisms, yet disruption of its homeostasis, particularly in labile forms that can contribute to oxidative stress, is connected to diseases ranging from infection to cancer to neurodegeneration. Iron deficiency is also among the most common nutritional deficiencies worldwide. To advance studies of iron in healthy and disease states, we now report the synthesis and characterization of iron-caged luciferin-1 (ICL-1), a bioluminescent probe that enables longitudi ...[more]