Ontology highlight
ABSTRACT:
SUBMITTER: Sun T
PROVIDER: S-EPMC5715774 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Sun Tao T Zhang Yongzhi Y Power Chanikarn C Alexander Phillip M PM Sutton Jonathan T JT Aryal Muna M Vykhodtseva Natalia N Miller Eric L EL McDannold Nathan J NJ
Proceedings of the National Academy of Sciences of the United States of America 20171113 48
Cavitation-facilitated microbubble-mediated focused ultrasound therapy is a promising method of drug delivery across the blood-brain barrier (BBB) for treating many neurological disorders. Unlike ultrasound thermal therapies, during which magnetic resonance thermometry can serve as a reliable treatment control modality, real-time control of modulated BBB disruption with undetectable vascular damage remains a challenge. Here a closed-loop cavitation controlling paradigm that sustains stable cavit ...[more]