Ontology highlight
ABSTRACT:
SUBMITTER: Huang TY
PROVIDER: S-EPMC5716044 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Huang Timothy Y TY Zhao Yingjun Y Jiang Lu-Lin LL Li Xiaoguang X Liu Yan Y Sun Yu Y Piña-Crespo Juan C JC Zhu Bing B Masliah Eliezer E Willnow Thomas E TE Pasquale Elena B EB Xu Huaxi H
The Journal of experimental medicine 20171107 12
Sortilin-related receptor with LDLR class A repeats (SORLA, SORL1, or LR11) is a genetic risk factor associated with Alzheimer's disease (AD). Although SORLA is known to regulate trafficking of the amyloid β (Aβ) precursor protein to decrease levels of proteotoxic Aβ oligomers, whether SORLA can counteract synaptic dysfunction induced by Aβ oligomers remains unclear. Here, we show that SORLA interacts with the EphA4 receptor tyrosine kinase and attenuates ephrinA1 ligand-induced EphA4 clustering ...[more]