Ontology highlight
ABSTRACT:
SUBMITTER: Court H
PROVIDER: S-EPMC5716267 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Court Helen H Ahearn Ian M IM Amoyel Marc M Bach Erika A EA Philips Mark R MR
The Journal of cell biology 20171019 12
Isoprenylcysteine carboxyl methyltransferase (ICMT) methylesterifies C-terminal prenylcysteine residues of CaaX proteins and some RAB GTPases. Deficiency of either ICMT or NOTCH1 accelerates pancreatic neoplasia in <i>Pdx1-Cre</i>;<i>LSL-Kras<sup>G12D</sup></i> mice, suggesting that ICMT is required for NOTCH signaling. We used <i>Drosophila melanogaster</i> wing vein and scutellar bristle development to screen Rab proteins predicted to be substrates for ICMT (ste14 in flies). We identified Rab7 ...[more]