Ontology highlight
ABSTRACT:
SUBMITTER: Pandzic T
PROVIDER: S-EPMC5716757 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Pandzic Tatjana T Rendo Veronica V Lim Jinyeong J Larsson Chatarina C Larsson Jimmy J Stoimenov Ivaylo I Kundu Snehangshu S Ali Muhammad Akhtar MA Hellström Mats M He Liqun L Lindroth Anders M AM Sjöblom Tobias T
Oncotarget 20171009 58
The chromatin modifier <i>PRDM2/RIZ1</i> is inactivated by mutation in several forms of cancer and is a putative tumor suppressor gene. Frameshift mutations in the C-terminal region of <i>PRDM2</i>, affecting (A)8 or (A)9 repeats within exon 8, are found in one third of colorectal cancers with microsatellite instability, but the contribution of these mutations to colorectal tumorigenesis is unknown. To model somatic mutations in microsatellite unstable tumors, we devised a general approach to pe ...[more]