New Perspectives on Pheochromocytoma and Paraganglioma: Toward a Molecular Classification.
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SUBMITTER: Crona J
PROVIDER: S-EPMC5716829 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
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New Perspectives on Pheochromocytoma and Paraganglioma: Toward a Molecular Classification.
Crona Joakim J Taïeb David D Pacak Karel K
Endocrine reviews 20171201 6
A molecular biology-based taxonomy has been proposed for pheochromocytoma and paraganglioma (PPGL). Data from the Cancer Genome Atlas revealed clinically relevant prognostic and predictive biomarkers and stratified PPGLs into three main clusters. Each subgroup has a distinct molecular-biochemical-imaging signature. Concurrently, new methods for biochemical analysis, functional imaging, and medical therapies have also become available. The research community now strives to match the cluster bioma ...[more]
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