Ontology highlight
ABSTRACT:
SUBMITTER: Ma X
PROVIDER: S-EPMC5717138 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Ma Xiaolu X Liu Hongmei H Li Jing J Wang Yihao Y Ding Yue-He YH Shen Hongyan H Yang Yeran Y Sun Chenyi C Huang Min M Tu Yingfeng Y Liu Yang Y Zhao Yongliang Y Dong Meng-Qiu MQ Xu Ping P Tang Tie-Shan TS Guo Caixia C
Nature communications 20171205 1
DNA polymerase η (Polη) facilitates translesion DNA synthesis (TLS) across ultraviolet (UV) irradiation- and cisplatin-induced DNA lesions implicated in skin carcinogenesis and chemoresistant phenotype formation, respectively. However, whether post-translational modifications of Polη are involved in these processes remains largely unknown. Here, we reported that human Polη undergoes O-GlcNAcylation at threonine 457 by O-GlcNAc transferase upon DNA damage. Abrogation of this modification results ...[more]