Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?

ABSTRACT: OBJECTIVE:The aim of this observational study was to clarify the link between vitamin D status and metabolic syndrome (MetS) in people with visceral obesity. DESIGN AND METHODS:One hundred ninety-six consecutive patients (152 women; mean age 51?±?13 years) with visceral obesity (mean body weight 103?±?20?kg, mean waist circumference (WC) 119?±?13?cm) were enrolled at the Obesity Outpatient Clinic of the University of Insubria in Varese. Anthropometric measurements were recorded. Laboratory tests, including vitamin D (25(OH)D)), fasting blood glucose (FBG), lipid profile, liver and kidney function tests were assessed. Vitamin D status was defined according to the European Society of Endocrinology guidelines, MetS to the 2009 harmonized definition. RESULTS:An inverse association emerged among 25(OH)D, body mass index (BMI) (P?=?0.001) and WC (all P?=?0.003). Serum 25(OH)D levels were inversely related to FBG and systolic blood pressure (SBP) (respectively, P?=?0.01 and 0.02). Median serum 25(OH)D levels were 13.3?ng/mL (CI 95% 12; 15) in MetS and 16 ng/mL (CI 95% 14; 18) (P?=?0.01) in non-MetS patients. Among patients with MetS, lower 25(OH)D concentrations were related to higher risk of hypertension (HT) (odds ratio (OR) 1.7, CI 95%, 0.7;4) and hyperglycemia (IFG)/type 2 diabetes (OR 5.5, CI 95% 2; 14). CONCLUSION:Vitamin D status and MetS are inversely correlated in visceral obesity, particularly with regard to glucose homeostasis and BP. More extensive studies are required to investigate the potential for causality.

SUBMITTER: Piantanida E 

PROVIDER: S-EPMC5717541 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature