Ontology highlight
ABSTRACT:
SUBMITTER: Yates EV
PROVIDER: S-EPMC5717618 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
The journal of physical chemistry. B 20160229 9
We have explored amyloid formation using poly(amino acid) model systems in which differences in peptide secondary structure and hydrophobicity can be introduced in a controlled manner. We show that an environmentally sensitive fluorescent dye, dapoxyl, is able to identify β-sheet structure and hydrophobic surfaces, structural features likely to be related to toxicity, as a result of changes in its excitation and emission profiles and its relative quantum yield. These results show that dapoxyl is ...[more]