The cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 UK Biobank participants.

ABSTRACT:

Objective

There has been a significant increase in the prescribing of medication for chronic non-cancer pain. In a UK population sample, we aimed to assess cardio-metabolic (CM) health in those taking these chronic pain medications.

Methods

133,401 participants from the UK Biobank cohort were studied. BMI, waist cm and hypertension were compared between those on drugs prescribed for chronic pain and CM drugs to those on CM drugs only. Multiple confounders were controlled for.

Results

Those taking opiates and CM drugs had the worst CM health profile with a 95%, 82% and 63% increased odds of reporting obesity, 'very high risk' waist circumference and hypertension, respectively (OR [95% CI] 1.95 [1.75-2.17], 1.82 [1.63-2.03], 1.63 [1.45-1.84]), compared to those on CM dr

SUBMITTER: Cassidy S 

PROVIDER: S-EPMC5718411 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature