Parkin and PINK1 functions in oxidative stress and neurodegeneration.
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ABSTRACT:
SUBMITTER: Barodia SK
PROVIDER: S-EPMC5718625 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Parkin and PINK1 functions in oxidative stress and neurodegeneration.
Barodia Sandeep K SK Creed Rose B RB Goldberg Matthew S MS
Brain research bulletin 20161223
Loss-of-function mutations in the genes encoding Parkin and PINK1 are causally linked to autosomal recessive Parkinson's disease (PD). Parkin, an E3 ubiquitin ligase, and PINK1, a mitochondrial-targeted kinase, function together in a common pathway to remove dysfunctional mitochondria by autophagy. Presumably, deficiency for Parkin or PINK1 impairs mitochondrial autophagy and thereby increases oxidative stress due to the accumulation of dysfunctional mitochondria that release reactive oxygen spe ...[more]
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