Ontology highlight
ABSTRACT:
SUBMITTER: Hu X
PROVIDER: S-EPMC5718827 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Hu Xintao X Valentin Antonio A Rosati Margherita M Manocheewa Siriphan S Alicea Candido C Chowdhury Bhabadeb B Bear Jenifer J Broderick Kate E KE Sardesai Niranjan Y NY Gall Sylvie Le SL Mullins James I JI Pavlakis George N GN Felber Barbara K BK
Human vaccines & immunotherapeutics 20170705 12
Sequence diversity and immunodominance are major obstacles in the design of an effective vaccine against HIV. HIV Env is a highly-glycosylated protein composed of 'conserved' and 'variable' regions. The latter contains immunodominant epitopes that are frequently targeted by the immune system resulting in the generation of immune escape variants. This work describes 12 regions in HIV Env that are highly conserved throughout the known HIV M Group sequences (Env CE), and are poorly immunogenic in m ...[more]