Ontology highlight
ABSTRACT:
SUBMITTER: Dong AC
PROVIDER: S-EPMC5718882 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Dong Alisa C AC Rivella Stefano S
Advances in experimental medicine and biology 20170101
Beta-thalassemia and sickle cell anemia are two of the most common diseases related to the hemoglobin protein. In these diseases, the beta-globin gene is mutated, causing severe anemia and ineffective erythropoiesis. Patients can additionally present with a number of life-threatening co-morbidities, such as stroke or spontaneous fractures. Current treatment involves transfusion and iron chelation; allogeneic bone marrow transplant is the only curative option, but is limited by the availability o ...[more]