Metabolic health across the BMI spectrum in HIV-infected and HIV-uninfected men.

ABSTRACT: OBJECTIVES:In the general population, metabolic health often declines as BMI increases. However, some obese individuals maintain metabolic health. HIV and antiretroviral therapy have been associated with metabolic disturbances. We hypothesized that HIV-infected (HIV) men on suppressive antiretroviral therapy experience less metabolic health than HIV-uninfected (HIV) men across all BMI categories. DESIGN/METHODS:In a cross-sectional analysis of 1018 HIV and 1092 HIV men enrolled in the multicenter AIDS cohort study, Poisson regression with robust variance determined associations between HIV serostatus and metabolic health prevalence (defined as meeting ?2 of 5 National Cholesterol Education Program Adult Treatment Panel III metabolic syndrome criteria), adjusting for age, race, BMI category, smoking, and hepatitis C virus infection status. RESULTS:HIV men were younger (54 vs. 59 years) and had lower median BMI (25 vs. 27?kg/m). Nonobese HIV men had lower metabolic health prevalence than HIV men (BMI ?25?kg/m: 80 vs. 94%, P?

SUBMITTER: Lake JE 

PROVIDER: S-EPMC5718950 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature