Dataset Information

A PLAG1 mutation contributed to stature recovery in modern cattle.

ABSTRACT: The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of ~1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16th and 18th centuries. Towards the 19th and 20th centuries, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait.

SUBMITTER: Utsunomiya YT

PROVIDER: S-EPMC5719367 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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A PLAG1 mutation contributed to stature recovery in modern cattle.

Utsunomiya Yuri Tani YT Milanesi Marco M Utsunomiya Adam Taiti Harth ATH Torrecilha Rafaela Beatriz Pintor RBP Kim Eui-Soo ES Costa Márcio Silva MS Aguiar Tamíris Sayuri TS Schroeder Steven S do Carmo Adriana Santana AS Carvalheiro Roberto R Neves Haroldo Henrique Rezende HHR Padula Romulo Cláudio Morozini RCM Sussai Thayla Souza TS Zavarez Ludmilla Balbo LB Cipriano Rafael Silva RS Caminhas Maria Margareth Theodoro MMT Hambrecht George G Colli Licia L Eufemi Elisa E Ajmone-Marsan Paolo P Cesana Deneb D Sannazaro Marco M Buora Maurizio M Morgante Michele M Liu George G Bickhart Derek D Van Tassell Curtis Paul CP Sölkner Johann J Sonstegard Tad Stewart TS Garcia José Fernando JF

Scientific reports 20171207 1

The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of ~1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16<sup>th</sup ...[more]

PMID: 29215042

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Project description:Domestic animals can serve as model systems of adaptive introgression and their genomic signatures. In part, their usefulness as model systems is due to their well-known histories. Different breeding strategies such as introgression and artificial selection have generated numerous desirable phenotypes and superior performance in domestic animals. The modern Danish Red Dairy Cattle is studied as an example of an introgressed population. It originates from crossing the traditional Danish Red Dairy Cattle with the Holstein and Brown Swiss breeds, both known for high milk production. This crossing happened, among other things due to changes in the production system, to raise milk production and overall performance. The genomes of modern Danish Red Dairy Cattle are heavily influenced by regions introgressed from the Holstein and Brown Swiss breeds and under subsequent selection in the admixed population. The introgressed proportion of the genome was found to be highly variable across the genome. Haplotypes introgressed from Holstein and Brown Swiss contained or overlapped known genes affecting milk production, as well as protein and fat content (CD14, ZNF215, BCL2L12, and THRSP for Holstein origin and ITPR2, BCAT1, LAP3, and MED28 for Brown Swiss origin). Genomic regions with high introgression signals also contained genes and enriched QTL associated with calving traits, body confirmation, feed efficiency, carcass, and fertility traits. These introgressed signals with relative identity-by-descent scores larger than the median showing Holstein or Brown Swiss introgression are mostly significantly correlated with the corresponding test statistics from signatures of selection analyses in modern Danish Red Dairy Cattle. Meanwhile, the putative significant introgressed signals have a significant dependency with the putative significant signals from signatures of selection analyses. Artificial selection has played an important role in the genomic footprints of introgression in the genome of modern Danish Red Dairy Cattle. Our study on a modern cattle breed contributes to an understanding of genomic consequences of selective introgression by demonstrating the extent to which adaptive effects contribute to shape the specific genomic consequences of introgression.

Dataset Information

A PLAG1 mutation contributed to stature recovery in modern cattle.

Publications

A PLAG1 mutation contributed to stature recovery in modern cattle.

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