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A positive genetic correlation between hypoxia tolerance and heat tolerance supports a controversial theory of heat stress.


ABSTRACT: We used quantitative genetics to test a controversial theory of heat stress, in which animals overheat when the demand for oxygen exceeds the supply. This theory, referred to as oxygen- and capacity-limited thermal tolerance, predicts a positive genetic correlation between hypoxia tolerance and heat tolerance. We demonstrate the first genetic correlation of this kind in a model organism, Drosophila melanogaster Genotypes more likely to fly under hypoxic stress (12% O2) were also more likely to fly under heat stress (39°C). This finding prompts new questions about mechanisms and limits of adaptation to heat stress.

SUBMITTER: Teague C 

PROVIDER: S-EPMC5719369 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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A positive genetic correlation between hypoxia tolerance and heat tolerance supports a controversial theory of heat stress.

Teague Collin C   Youngblood Jacob P JP   Ragan Kinley K   Angilletta Michael J MJ   VandenBrooks John M JM  

Biology letters 20171101 11


We used quantitative genetics to test a controversial theory of heat stress, in which animals overheat when the demand for oxygen exceeds the supply. This theory, referred to as oxygen- and capacity-limited thermal tolerance, predicts a positive genetic correlation between hypoxia tolerance and heat tolerance. We demonstrate the first genetic correlation of this kind in a model organism, <i>Drosophila melanogaster</i> Genotypes more likely to fly under hypoxic stress (12% O<sub>2</sub>) were als  ...[more]

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