Ontology highlight
ABSTRACT:
SUBMITTER: Widman DG
PROVIDER: S-EPMC5719398 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Widman Douglas G DG Young Ellen E Nivarthi Usha U Swanstrom Jesica A JA Royal Scott R SR Yount Boyd L BL Debbink Kari K Begley Matthew M Marcet Stephanie S Durbin Anna A de Silva Aravinda M AM Messer William B WB Baric Ralph S RS
Scientific reports 20171207 1
Dengue vaccine trials have revealed deficits in our understanding of the mechanisms of protective immunity, demonstrating a need to measure epitope-specific antibody responses against each DENV serotype. HmAb 5J7 binds to a complex, 3-monomer spanning quaternary epitope in the DENV3 envelope (E) protein, but it is unclear whether all interactions are needed for neutralization. Structure guided design and reverse genetics were used to sequentially transplant larger portions of the DENV3-specific ...[more]