Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever.
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ABSTRACT:
SUBMITTER: Mire CE
PROVIDER: S-EPMC5719877 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever.
Mire Chad E CE Cross Robert W RW Geisbert Joan B JB Borisevich Viktoriya V Agans Krystle N KN Deer Daniel J DJ Heinrich Megan L ML Rowland Megan M MM Goba Augustine A Momoh Mambu M Boisen Mathew L ML Grant Donald S DS Fullah Mohamed M Khan Sheik Humarr SH Fenton Karla A KA Robinson James E JE Branco Luis M LM Garry Robert F RF Geisbert Thomas W TW
Nature medicine 20170904 10
There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoproteins of all four clades of Lassa virus is able to rescue 100% of cynomolgus macaques when treatment is initiated at advanced stages of disease, including up to 8 d after challenge. ...[more]
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