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Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever.


ABSTRACT: There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoproteins of all four clades of Lassa virus is able to rescue 100% of cynomolgus macaques when treatment is initiated at advanced stages of disease, including up to 8 d after challenge.

SUBMITTER: Mire CE 

PROVIDER: S-EPMC5719877 | biostudies-literature |

REPOSITORIES: biostudies-literature

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