Ontology highlight
ABSTRACT:
SUBMITTER: Krasemann S
PROVIDER: S-EPMC5719893 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Krasemann Susanne S Madore Charlotte C Cialic Ron R Baufeld Caroline C Calcagno Narghes N El Fatimy Rachid R Beckers Lien L O'Loughlin Elaine E Xu Yang Y Fanek Zain Z Greco David J DJ Smith Scott T ST Tweet George G Humulock Zachary Z Zrzavy Tobias T Conde-Sanroman Patricia P Gacias Mar M Weng Zhiping Z Chen Hao H Tjon Emily E Mazaheri Fargol F Hartmann Kristin K Madi Asaf A Ulrich Jason D JD Glatzel Markus M Worthmann Anna A Heeren Joerg J Budnik Bogdan B Lemere Cynthia C Ikezu Tsuneya T Heppner Frank L FL Litvak Vladimir V Holtzman David M DM Lassmann Hans H Weiner Howard L HL Ochando Jordi J Haass Christian C Butovsky Oleg O
Immunity 20170901 3
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a specific apolipoprotein E (APOE)-dependent molecular signature in microglia from models of amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Alzheimer's disease (AD) and in microglia surrounding neuritic β-amyloid (Aβ)-plaques in the brains of people with AD. The APOE pathway mediated a switch from a homeostatic to a neurodegenera ...[more]