Ontology highlight
ABSTRACT:
SUBMITTER: Braga RC
PROVIDER: S-EPMC5720373 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Braga Rodolpho C RC Alves Vinicius M VM Silva Meryck F B MF Muratov Eugene E Fourches Denis D Lião Luciano M LM Tropsha Alexander A Andrade Carolina H CH
Molecular informatics 20150720 10
The blockage of the hERG K(+) channels is closely associated with lethal cardiac arrhythmia. The notorious ligand promiscuity of this channel earmarked hERG as one of the most important antitargets to be considered in early stages of drug development process. Herein we report on the development of an innovative and freely accessible web server for early identification of putative hERG blockers and non-blockers in chemical libraries. We have collected the largest publicly available curated hERG d ...[more]