Ontology highlight
ABSTRACT:
SUBMITTER: Rogers KW
PROVIDER: S-EPMC5720593 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Rogers Katherine W KW Lord Nathan D ND Gagnon James A JA Pauli Andrea A Zimmerman Steven S Aksel Deniz C DC Reyon Deepak D Tsai Shengdar Q SQ Joung J Keith JK Schier Alexander F AF
eLife 20171207
Developmental signaling pathways often activate their own inhibitors. Such inhibitory feedback has been suggested to restrict the spatial and temporal extent of signaling or mitigate signaling fluctuations, but these models are difficult to rigorously test. Here, we determine whether the ability of the mesendoderm inducer Nodal to activate its inhibitor Lefty is required for development. We find that zebrafish <i>lefty</i> mutants exhibit excess Nodal signaling and increased specification of mes ...[more]