Ontology highlight
ABSTRACT:
SUBMITTER: Matsuda T
PROVIDER: S-EPMC5721436 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Matsuda Takashi T Takami Taro T Sasaki Ryo R Nishimura Tatsuro T Aibe Yuki Y Paredes Bruno Diaz BD Quintanilha Luiz Fernando LF Matsumoto Toshihiko T Ishikawa Tsuyoshi T Yamamoto Naoki N Tani Kenji K Terai Shuji S Taura Yasuho Y Sakaida Isao I
Hepatology communications 20170717 7
We have been developing a therapy for liver cirrhosis using cultured autologous bone marrow-derived mesenchymal stem cells (BMSCs). Before human clinical trials can be considered, the safety and efficacy of BMSC infusion in medium to large animals must be confirmed; thus, we developed a canine liver fibrosis model. A small amount of bone marrow fluid was aspirated from the canine humerus to assess the characteristics of BMSCs. We implanted a venous catheter in the stomach and a subcutaneous infu ...[more]