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Treating fatty liver disease by modulating mitochondrial pyruvate metabolism.

ABSTRACT: Modifying the entry of pyruvate into mitochondria may provide a unique approach to treat metabolic disease. The pharmacology of a new class of insulin sensitizers directed against a newly identified mitochondrial target may treat many aspects of nonalcoholic steatohepatitis, including fibrosis. This commentary suggests treating nonalcoholic steatohepatitis through a newly identified mechanism consistent with pathophysiology. (Hepatology Communications 2017;1:193-197).

SUBMITTER: Colca JR

PROVIDER: S-EPMC5721453 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Treating fatty liver disease by modulating mitochondrial pyruvate metabolism.

Colca Jerry R JR McDonald William G WG McCommis Kyle S KS Finck Brian N BN

Hepatology communications 20170418 3

Modifying the entry of pyruvate into mitochondria may provide a unique approach to treat metabolic disease. The pharmacology of a new class of insulin sensitizers directed against a newly identified mitochondrial target may treat many aspects of nonalcoholic steatohepatitis, including fibrosis. This commentary suggests treating nonalcoholic steatohepatitis through a newly identified mechanism consistent with pathophysiology. (<i>Hepatology Communications</i> 2017;1:193-197). ...[more]

PMID: 29404453

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