Complex roles of myoglianin in regulating adult performance and lifespan.
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ABSTRACT:
SUBMITTER: Augustin H
PROVIDER: S-EPMC5721940 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Complex roles of myoglianin in regulating adult performance and lifespan.
Augustin Hrvoje H Adcott Jennifer J Elliott Christopher J H CJH Partridge Linda L
Fly 20170824 4
Myoglianin, the Drosophila homolog of the secreted vertebrate proteins Myostatin and GDF-11, is an important regulator of neuronal modeling, and synapse function and morphology. While Myoglianin suppression during development elicits positive effects on the neuromuscular system, genetic manipulations of myoglianin expression levels have a varied effect on the outcome of performance tests in aging flies. Specifically, Myoglianin preserves jumping ability, has no effect on negative geotaxis, and n ...[more]
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