Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain.

ABSTRACT:

Methods

Seven healthy volunteers underwent PET scans with [18F]altanserin and [11C]FLB 457 for 5-HT2A and D2 receptors, respectively. As a measure of receptor density, a binding potential (BP) was calculated from PET data for 76 cerebral cortical regions. A correlation matrix was calculated between the binding potentials of [18F]altanserin and [11C]FLB 457 for those regions. The regional relationships were investigated using a bicluster analysis of the correlation matrix with an iterative signature algorithm.

Results

We identified two clusters of regions. The first cluster identified a distinct profile of correlation coefficients between 5-HT2A and D2 receptors, with the former in regions related to sensorimotor integration (supplementary motor area, superior parietal gyrus,

SUBMITTER: Ishii T 

PROVIDER: S-EPMC5722317 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature