Ontology highlight
ABSTRACT:
SUBMITTER: Taromi S
PROVIDER: S-EPMC5722545 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Taromi Sanaz S Lewens Florentine F Arsenic Ruza R Sedding Dagmar D Sänger Jörg J Kunze Almut A Möbs Markus M Benecke Joana J Freitag Helma H Christen Friederike F Kaemmerer Daniel D Lupp Amelie A Heilmann Mareike M Lammert Hedwig H Schneider Claus-Peter CP Richter Karen K Hummel Michael M Siegmund Britta B Burger Meike M Briest Franziska F Grabowski Patricia P
Oncotarget 20170923 57
Small cell lung cancer (SCLC) is an aggressive cancer showing a very poor prognosis because of metastasis formation at an early stage and acquisition of chemoresistance. One key driver of chemoresistance is the transcription factor Forkhead box protein M1 (FOXM1) that regulates cell cycle proliferation, maintenance of genomic stability, DNA damage response, and cell differentiation in numerous tumor entities. In this study we investigated the role of FOXM1 in SCLC progression and analyzed the ef ...[more]