Ontology highlight
ABSTRACT:
SUBMITTER: Komolov KE
PROVIDER: S-EPMC5722692 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Komolov Konstantin E KE Benovic Jeffrey L JL
Cellular signalling 20170712
This review is provided in recognition of the extensive contributions of Dr. Robert J. Lefkowitz to the G protein-coupled receptor (GPCR) field and to celebrate his 75th birthday. Since one of the authors trained with Bob in the 80s, we provide a history of work done in the Lefkowitz lab during the 80s that focused on dissecting the mechanisms that regulate GPCR signaling, with a particular emphasis on the GPCR kinases (GRKs). In addition, we highlight structure/function characteristics of GRK i ...[more]