Bringing the HEET: The Argument for High-Efficacy Early Treatment for Pediatric-Onset Multiple Sclerosis.
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ABSTRACT:
SUBMITTER: McGinley M
PROVIDER: S-EPMC5722772 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Bringing the HEET: The Argument for High-Efficacy Early Treatment for Pediatric-Onset Multiple Sclerosis.
McGinley Marisa M Rossman Ian T IT
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20171001 4
Pediatric-onset multiple sclerosis (POMS) is rarer than adult-onset disease, and represents a different diagnostic and treatment challenge to clinicians. We review POMS clinical and radiographic presentations, and explore important differences between POMS and adult-onset MS natural histories and long-term outcomes. Despite having more active disease, current treatment guidelines for patients with POMS endorse the off-label use of lower-efficacy disease-modifying therapies (DMTs) as first line. ...[more]
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